Efficacy of Acellular Pertussis Vaccine

Acellular pertussis vaccine efficacy: An updated systematic review and meta –analysis

Background: Recent studies indicate an increased incidence of pertussis disease in recent years. The aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the Expanded Program on Immunization) and for high-risk adults in Iran through updating current best available evidence.   Methods: We performed a syste...

Acellular pertussis vaccine for adolescents.

BACKGROUND The use of whole-cell pertussis vaccine has led to a significant decline in incidence of the disease among children. This change in the epidemiological profile led to an increased number of cases among teenagers and adults, as a result of loss of immunity to the disease or vaccine after approximately 10 years. An increased number of cases was also observed among non-immunized or part...

Lipopolysaccharide analogs improve efficacy of acellular pertussis vaccine and reduce type I hypersensitivity in mice.

Pertussis is an infectious disease of the respiratory tract that is caused by the gram-negative bacterium Bordetella pertussis. Although acellular pertussis (aP) vaccines are safe, they are not fully effective and thus require improvement. In contrast to whole-cell pertussis (wP) vaccines, aP vaccines do not contain lipopolysaccharide (LPS). Monophosphoryl lipid A (MPL) and Neisseria meningitid...

Estimating the Effectiveness of Tetanus-Diphtheria-Acellular Pertussis Vaccine

TO THE EDITOR—We read with interest Koepke et al’s analysis [1] of Wisconsin Immunization Registry (WIR) and pertussis surveillance databases to determine effectiveness of tetanus-diphtheria-acellular pertussis (Tdap) vaccines. We are familiar with the challenges involved in using such data sources to evaluate the performance of pertussis vaccines, as we have been collaborating since 2008 in a ...

acellular pertussis vaccine: iran’s next step to control the disease?